A thiazolo[5,4- <i>d</i> ]thiazole-bridged dinuclear iridium( <scp>iii</scp> ) photosensitizer induces ferroptosis for boosting photoimmunotherapy against hypoxic melanoma
Incorporation of a thiazolo[5,4-<i>d</i>]thiazole moiety into a dinuclear Ir(III) complex yields a novel Type I/II photosensitizer. Upon irradiation, this dinuclear complex generates substantial reactive oxygen species, triggering ferroptosis and subsequent immunogenic cell death (ICD). This design enables potent hypoxic melanoma ablation concurrent with ICD signal induction.
Authors
- Hui Chao (ORCID: https://orcid.org/0000-0003-4153-5303)
- Jinzhe Liang (ORCID: https://orcid.org/0000-0001-6721-890X)
- Hui Jiang (ORCID: https://orcid.org/0000-0002-4534-1322)
- Jiahao Zeng
- Fan Wang (ORCID: https://orcid.org/0000-0003-3542-6960)
- Jinrong Yang (ORCID: https://orcid.org/0000-0002-0248-8041)
- Qiaoshan Lie
Institutions
- Hunan University of Science and Technology (CN)
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc05288b
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00