Membranous Labyrinth Position in the Lateral Semicircular Canal: Considerations for Gene Therapy Delivery
This consistent finding, independent of disease state, indicates that fenestration at the lateral canal apex carries a high risk of membranous injury. Potential consequences include hearing loss, vestibular dysfunction, and reduced therapeutic effect. Inadvertent entry into the endolymphatic compartment might not adequately support perilymphatic flow and compromise therapeutic delivery. Because fenestration of the outer circumference of the lateral semicircular canal is histologically unfavorable, histologic assessment of proposed fenestration sites is necessary.
Authors
- Józef Mierzwiński (ORCID: https://orcid.org/0000-0003-2668-4570)
- Rafael da Costa Monsanto
- Michael D. Puricelli (ORCID: https://orcid.org/0000-0002-1612-5786)
- Maurizio Falcioni (ORCID: https://orcid.org/0000-0003-2455-8298)
- Andrew J. Fishman
- Arnaldo L. Rivera
- Koffi L. Lakpa (ORCID: https://orcid.org/0000-0002-7454-6079)
- Brian P. Miller (ORCID: https://orcid.org/0000-0001-5614-5303)
- Sebahattin Cüreoǧlu (ORCID: https://orcid.org/0000-0001-9220-7073)
- Maya N. Matabele (ORCID: https://orcid.org/0000-0002-0873-3730)
- John P. Dahl (ORCID: https://orcid.org/0000-0003-2728-3576)
- Nevra Keskin‐Yilmaz
Institutions
- University of Parma (IT)
- University of Minnesota (US)
- Children's Mercy Hospital (US)
- University of Wisconsin–Madison (US)
- University of Bydgoszcz (PL)
- University of Kansas Medical Center (US)
- University of Missouri (US)
Publication Details
- Journal
- OTO Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/oto2.70178
- Primary Topic
- Vestibular and auditory disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Minnesota