Omics‐derived biological modules reflect tau positron emission tomography in Alzheimer's disease
Integration of proteomics, transcriptomics, tau positron emission tomography (PET) imaging, and cognition in Alzheimer's disease.Fifteen key tau PET imaging biomarkers were prioritized.Fifty key tau-associated proteins were identified.Four distinct molecular networks contribute to regional tau pathology and cognition.Modules 1 (metabolic-cytoskeletal) and 3 (adhesion-nutrient sensing) strongly associated with tau PET burden and cognitive impairment.
Authors
- Huiqin Liu (ORCID: https://orcid.org/0000-0002-5754-2623)
- Chang‐Yi Shen
- Qiao Sun (ORCID: https://orcid.org/0000-0002-8770-7847)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2667-281X)
- Hang Su (ORCID: https://orcid.org/0000-0002-5730-2259)
- Qing Ye (ORCID: https://orcid.org/0000-0003-1674-4066)
- Si‐Chun Gu
Institutions
- Fudan University (CN)
- Shanghai Mental Health Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
- National Neuroscience Institute (SG)
- Huashan Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70172
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Shen Kang Hospital Development Center