Noninvasive Detection of Occult yet Significant Liver Pathology in Alanine Aminotransferase–Normal Chronic Hepatitis B: A Multicenter Study
CK18-M65-centered biomarker models suggest promising noninvasive tools for detecting occult liver pathology and risk stratification of ALT-normal HBeAg+ CHB infection, potentially avoiding unnecessary biopsies while identifying candidates for early intervention, nonetheless requiring validation in larger cohorts.
Authors
- Xihong Wang (ORCID: https://orcid.org/0000-0002-8277-969X)
- Ming Lin (ORCID: https://orcid.org/0000-0003-3778-5924)
- Y. Zhang (ORCID: https://orcid.org/0000-0002-9741-6891)
- Shanshan Ji (ORCID: https://orcid.org/0000-0001-7944-8155)
- Pengyuan Kang
- Yizhong Hu (ORCID: https://orcid.org/0000-0001-9766-1902)
- Xiaoling Chi (ORCID: https://orcid.org/0000-0003-3193-1943)
- Meijie Shi (ORCID: https://orcid.org/0000-0001-9400-2442)
- Tao Shen (ORCID: https://orcid.org/0000-0002-1365-9862)
- Xiaoling Liu (ORCID: https://orcid.org/0009-0000-3860-975X)
- Xinjie Li (ORCID: https://orcid.org/0000-0003-2613-8270)
- Feng Guo (ORCID: https://orcid.org/0000-0001-5096-2142)
- Jinbao Huang (ORCID: https://orcid.org/0000-0003-2272-933X)
- Yingjie Qi (ORCID: https://orcid.org/0000-0002-9532-9233)
- Xiaozhong Wang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- University of Science and Technology of China (CN)
- Xinjiang Medical University (CN)
- Hefei University of Technology (CN)
- Peking University (CN)
- Chizhou University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Hefei First People's Hospital (CN)
- Hefei Infectious Disease Hospital (CN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1093/infdis/jiaf554
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00