The Effect of Time-Restricted Eating in People with Type 2 Diabetes Mellitus with Metabolic Dysfunction-Associated Steatohepatitis

Abstract The escalating epidemic of type 2 diabetes mellitus (T2DM) and its close association with metabolic dysfunction-associated steatohepatitis (MASH) necessitate urgent measures. Time-restricted eating (TRE) restricts daily food intake to specific time windows, typically ranging from 8 to 12 h, and contributes to maintaining various metabolic parameters of body. Aim: The aim of this study was to evaluate the effect of TRE in people with T2DM and MASH. Materials and Methods: This quasi-experimental pre–post study was conducted over 14 months at a tertiary care teaching hospital. This study comprised people with diabetes (PWD) with MASH, aged 18 to 70 years, of both sexes. A total of 87 participants were enrolled after initial assessment with weight, liver elastography, liver function test, fasting blood glucose (FBG), postprandial blood glucose (PPBG), serum lipid profile, HbA1c, and serum creatinine. Participants received counseling on TRE – eating within the time frame of 2:00 pm to 10:00 pm . Statistical Analysis Used: SPSS 21.0. Results: A total of 74 PWD with MASH (mean age: 49.18 years; 36 females and 38 males; mean body mass index [BMI]: 25.941) were on TRE for three months. The study observed a statistically significant reduction in controlled attenuated parameter and liver stiffness measurement score, weight, body mass index, HbA1c, FBG, PPBG, LDL cholesterol, and triglycerides. Conclusion: TRE can be a complementary strategy for managing diabetes and MASH, while also slowing the progression of MASH in individuals with type 2 DM.