Preoperative Pregabalin and the Cp50 for Skin Incision During Target-Controlled Propofol Infusion: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial
This study demonstrated that pretreatment with 300 mg pregabalin significantly reduced the Cp50 value of propofol by 44%, as calculated using the delta method. When 300 mg of pregabalin is administered before anesthesia and propofol is used for maintenance via TCI, a lower target effect-site concentration might be sufficient. Additionally, pregabalin premedication has the potential to decrease postoperative pain and opioid consumption.
Authors
- Birgit Reiter (ORCID: https://orcid.org/0000-0002-5352-4161)
- Stefan Ulbing (ORCID: https://orcid.org/0000-0002-3543-9342)
- Walter Plöchl (ORCID: https://orcid.org/0000-0003-3761-1326)
- Thomas Stimpfl (ORCID: https://orcid.org/0000-0003-0418-1809)
- Alexandra Gráf (ORCID: https://orcid.org/0000-0003-0035-2658)
- Johannes Müller (ORCID: https://orcid.org/0000-0003-1793-0143)
- Roxana Polojintef-Corbu
Institutions
- Statistics Austria (AT)
- Intensive Care Foundation (AU)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Anesthesia & Analgesia
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1213/ane.0000000000007824
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00