Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis
We identified potentially clinically relevant genetic variation in the alternative complement pathway that may contribute to individual susceptibility to bacteremia and sepsis syndromes. Further study is required to understand the mechanisms behind these associations and their clinical impacts.
Authors
- Myoungkeun Lee
- Faraaz Shah (ORCID: https://orcid.org/0000-0002-2847-7738)
- Hrishikesh S. Kulkarni (ORCID: https://orcid.org/0000-0003-4830-5084)
- Charles S. Dela Cruz (ORCID: https://orcid.org/0000-0002-5258-1797)
- Jonathan M. Chernus (ORCID: https://orcid.org/0000-0001-6555-1143)
- Jonathan K. Alder (ORCID: https://orcid.org/0000-0003-3741-6512)
- William Bain (ORCID: https://orcid.org/0000-0001-8506-0552)
- Nuala J. Meyer (ORCID: https://orcid.org/0000-0003-4597-5584)
- Timothy Dempsey (ORCID: https://orcid.org/0000-0002-6026-0846)
- Eleanor Feingold (ORCID: https://orcid.org/0000-0003-2898-6484)
- Florian Mayr (ORCID: https://orcid.org/0000-0002-2298-9011)
- Mehdi syed Nouraie (ORCID: https://orcid.org/0000-0001-7465-0581)
- Patrick J. Strollo
- Kyle Inman
- Viviana P. Ferreira (ORCID: https://orcid.org/0000-0001-8923-5671)
Institutions
- University of Toledo Medical Center (US)
- Oregon State University (US)
- University of California, Los Angeles (US)
- University of Pittsburgh (US)
- University of California System (US)
- VA Pittsburgh Healthcare System (US)
- University of Pennsylvania (US)
- University of Toledo (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1097/cce.0000000000001339
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00