Perilead Edema in Deep Brain Stimulation: Long-Term Outcomes and Etiologic Correlates
PLE is a frequent postsurgical event and may cause transient postoperative confusion. It seems linked to older age and multiple MER tracks. Although it does not influence global motor and neuropsychologic outcomes, PLE contributes to postoperative confusion episodes. To avoid PLE sequelae, using multiple MER tracks in older patients should be discouraged.
Authors
- Francesca Mameli (ORCID: https://orcid.org/0000-0003-4774-582X)
- Enrico Mailland
- Roberta Ferrucci (ORCID: https://orcid.org/0000-0001-5109-9483)
- Elena Pirola (ORCID: https://orcid.org/0000-0002-0766-2088)
- Giorgio Fiore (ORCID: https://orcid.org/0000-0003-4550-3675)
- Luigi Gianmaria Remore (ORCID: https://orcid.org/0000-0003-4118-9009)
- Giulio Bertani (ORCID: https://orcid.org/0000-0003-1470-3391)
- Marco Locatelli (ORCID: https://orcid.org/0000-0001-7138-8653)
- Ioannis U. Isaias (ORCID: https://orcid.org/0000-0002-3552-5144)
- Filippo Cogiamanian (ORCID: https://orcid.org/0000-0001-7810-5281)
- Giovanni Marfia (ORCID: https://orcid.org/0000-0002-5849-7000)
- Antonella Ampollini (ORCID: https://orcid.org/0000-0002-4384-345X)
- Fabiana Ruggiero (ORCID: https://orcid.org/0000-0003-0471-4476)
- Linda Borellini (ORCID: https://orcid.org/0000-0003-3659-1220)
- Stefania Elena Navone (ORCID: https://orcid.org/0000-0002-0097-9146)
- Eleonora Zirone (ORCID: https://orcid.org/0000-0002-0935-8645)
- Elena Scagliotti (ORCID: https://orcid.org/0009-0004-9102-7547)
Institutions
- University of Würzburg (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1016/j.neurom.2025.09.315
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Milano
- Dipartimenti di Eccellenza
- Ministero della Salute
- Ministero dell'Università e della Ricerca
- Center for Neurotechnology, University of Washington