Deep partially linear transformation model for right-censored survival data

Although the Cox proportional hazards (PH) model is well established and extensively used in the analysis of survival data, the PH assumption may not always hold in practical scenarios. The class of semiparametric transformation models extends the Cox model and also includes many other survival models as special cases. This paper introduces a deep partially linear transformation model as a general and flexible regression framework for right-censored data. The proposed method is capable of avoiding the curse of dimensionality while still retaining the interpretability of some covariates of interest. We derive the overall convergence rate of the maximum likelihood estimators, the minimax lower bound of the nonparametric deep neural network estimator, and the asymptotic normality and the semiparametric efficiency of the parametric estimator. Comprehensive simulation studies demonstrate the impressive performance of the proposed estimation procedure in terms of both the estimation accuracy and the predictive power, which is further validated by an application to a real-world dataset.

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Publication Details

Journal
Biometrics
Published
2025-10-08
DOI
https://doi.org/10.1093/biomtc/ujaf126
Citations
1
Primary Topic
Statistical Methods and Inference
Type
article
Field-Weighted Citation Impact
2.63
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article

Deep partially linear transformation model for right-censored survival data

Yue Zhang, Junkai Yin
1 citations
Biometrics
Statistical Methods and Inference
2.63
article

Deep partially linear transformation model for right-censored survival data

Yue Zhang, Junkai Yin
article en
1 citations

Abstract

Although the Cox proportional hazards (PH) model is well established and extensively used in the analysis of survival data, the PH assumption may not always hold in practical scenarios. The class of semiparametric transformation models extends the Cox model and also includes many other survival models as special cases. This paper introduces a deep partially linear transformation model as a general and flexible regression framework for right-censored data. The proposed method is capable of avoiding the curse of dimensionality while still retaining the interpretability of some covariates of interest. We derive the overall convergence rate of the maximum likelihood estimators, the minimax lower bound of the nonparametric deep neural network estimator, and the asymptotic normality and the semiparametric efficiency of the parametric estimator. Comprehensive simulation studies demonstrate the impressive performance of the proposed estimation procedure in terms of both the estimation accuracy and the predictive power, which is further validated by an application to a real-world dataset.

BiometricsVol. 81(4)
Shanghai Jiao Tong University (CN)
Openalex Percentile: Top 8%
Statistical Methods and Inference
2.63
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