Cysteine-activated hydrogen selenide (H <sub>2</sub> Se) delivery from isoselenocyanates

Hydrogen selenide (H<sub>2</sub>Se) is an emerging bioregulator and precursor to essential selenium-containing biomolecules. We show that aryl isoselenocyanates (ISeC-R) release H<sub>2</sub>Se upon activation by cysteine, and that electronic substitution can modulate the release profiles. We also demonstrate applications to live cell imaging, expanding available tools for investigating H<sub>2</sub>Se chemical biology.

Authors

Kaylin G. Fosnacht
Turner D. Newton (ORCID: https://orcid.org/0000-0002-9098-3463)
Arman C. Garcia (ORCID: https://orcid.org/0000-0001-8226-5544)
Christopher A. Steven
Michael D. Pluth (ORCID: https://orcid.org/0000-0003-3604-653X)
Keyan Li (ORCID: https://orcid.org/0000-0002-2126-6516)
Reis D. Dorit

Institutions

University of Oregon (US)

Publication Details

Journal: Chemical Communications
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5cc05352h
Primary Topic: Organoselenium and organotellurium chemistry
Type: article
Field-Weighted Citation Impact: 0.00

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article

Cysteine-activated hydrogen selenide (H ₂ Se) delivery from isoselenocyanates

Kaylin G. Fosnacht, Turner D. Newton, Arman C. Garcia, Christopher A. Steven et al.

Jan 1, 2025

Chemical Communications

Organoselenium and organotellurium chemistry

article

Cysteine-activated hydrogen selenide (H ₂ Se) delivery from isoselenocyanates

Kaylin G. Fosnacht, Turner D. Newton, Arman C. Garcia, Christopher A. Steven, Michael D. Pluth, Keyan Li, Reis D. Dorit

January 1, 2025article en

Abstract

Hydrogen selenide (H<sub>2</sub>Se) is an emerging bioregulator and precursor to essential selenium-containing biomolecules. We show that aryl isoselenocyanates (ISeC-R) release H<sub>2</sub>Se upon activation by cysteine, and that electronic substitution can modulate the release profiles. We also demonstrate applications to live cell imaging, expanding available tools for investigating H<sub>2</sub>Se chemical biology.

Chemical CommunicationsVol. 61(94)

University of Oregon (US)

Openalex Percentile: Top 70%

Organoselenium and organotellurium chemistry

DOI Source OpenAlex

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