Melatonin ameliorates bronchopulmonary dysplasia by modulating the NF-κB pathway via the gut microbiota-short-chain fatty acid axis
Melatonin ameliorates BPD by modulating the gut microbiota-SCFA metabolic axis, which in turn suppresses NF-κB pathway activation and pyroptosis in lung tissues via systemic circulation. This finding suggests a novel therapeutic strategy for the treatment of BPD.
Authors
- Run-zhong Huang
- Wu Dong (ORCID: https://orcid.org/0000-0002-2372-2415)
- Dan Huang (ORCID: https://orcid.org/0000-0001-9079-0955)
- Dabin Huang (ORCID: https://orcid.org/0000-0003-1533-9413)
- Fei Li (ORCID: https://orcid.org/0009-0006-1479-2821)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-1160-2715)
- Bin Wu (ORCID: https://orcid.org/0000-0001-9078-386X)
- Hao Hu (ORCID: https://orcid.org/0000-0002-4604-6333)
- Qi Luo (ORCID: https://orcid.org/0000-0001-6393-0115)
- Hongfu Li (ORCID: https://orcid.org/0000-0002-3876-8272)
- Jinfeng Zhang
- Xuanna Zhao
- Jiahao Lai (ORCID: https://orcid.org/0009-0005-9746-514X)
- Yue Wang (ORCID: https://orcid.org/0000-0002-4501-8699)
Institutions
- Guangdong Medical College (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1016/j.intimp.2025.115730
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00