Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis

Causal forest modeling enables the detection of HTEs of AR in patients with HCC based on multiple clinical-radiological characteristics. Radiological tumor size ≤5 cm and non-smooth tumor margins were identified as significant modifiers and should be taken into consideration when selecting between AR and non-AR. Based on these findings, over 30% of the study population who underwent non-AR might have experienced a reduced risk of early recurrence and improved RFS if AR had been performed, thereby supporting the importance of personalized selection of the optimal hepatectomy type in patients with HCC.

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Publication Details

Journal
JHEP Reports
Published
2025-08-25
DOI
https://doi.org/10.1016/j.jhepr.2025.101565
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
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article

Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis

Tianyu Tang, Xiangming Fang, Tianyi Xia, Xueying Long et al.
JHEP Reports
Hepatocellular Carcinoma Treatment and Prognosis
article

Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis

Tianyu Tang, Xiangming Fang, Tianyi Xia, Xueying Long, Fang‐Ming Chen, Xiangpan Meng, Yu Qian, Jitao Wang, Yongping Zhou, Wenbo Xiao, Yibing Shi, Ben Y. Zhao, Xinying Qu, Shenghong Ju
article en

Abstract

Causal forest modeling enables the detection of HTEs of AR in patients with HCC based on multiple clinical-radiological characteristics. Radiological tumor size ≤5 cm and non-smooth tumor margins were identified as significant modifiers and should be taken into consideration when selecting between AR and non-AR. Based on these findings, over 30% of the study population who underwent non-AR might have experienced a reduced risk of early recurrence and improved RFS if AR had been performed, thereby supporting the importance of personalized selection of the optimal hepatectomy type in patients with HCC.

JHEP ReportsVol. 7(11)
Hebei Medical University (CN), Jiangnan University (CN), Central South University (CN), Zhongda Hospital Southeast University (CN), Xingtai People's Hospital (CN), Xuzhou Central Hospital (CN), Wuxi People's Hospital (CN), Xiangya Hospital Central South University (CN), First Affiliated Hospital Zhejiang University (CN)
Openalex Percentile: Top 58%
Hepatocellular Carcinoma Treatment and Prognosis
DOIOpen Access PDFOpenAlex
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