Polygenic risk score for coronary artery disease across the spectrum of atherosclerotic disease
A CAD PRS was associated with incident major coronary events in all ASCVD categories. Although genetics provided the strongest relative association in patients without established ASCVD, the absolute risk gradient was comparable for patients with and without ASCVD.
Authors
- Deepak L. Bhatt (ORCID: https://orcid.org/0000-0002-1278-6245)
- Christian T. Ruff (ORCID: https://orcid.org/0000-0002-4712-3206)
- Elliott M. Antman (ORCID: https://orcid.org/0000-0002-0808-9199)
- Eugene Braunwald (ORCID: https://orcid.org/0000-0002-3472-626X)
- Frederick Kamanu (ORCID: https://orcid.org/0000-0001-7208-1047)
- Christopher P. Cannon (ORCID: https://orcid.org/0000-0003-4596-2791)
- Marc S. Sabatine (ORCID: https://orcid.org/0000-0002-0691-3359)
- Giorgio Melloni (ORCID: https://orcid.org/0000-0001-6371-1334)
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- Patrick T. Ellinor (ORCID: https://orcid.org/0000-0002-2067-0533)
- Michelle L. O’Donoghue (ORCID: https://orcid.org/0000-0002-8663-0067)
- André Zimerman (ORCID: https://orcid.org/0000-0001-8977-6929)
- Marc P. Bonaca (ORCID: https://orcid.org/0000-0002-9860-3584)
- Nicholas Marston (ORCID: https://orcid.org/0000-0001-6164-4617)
- Stephen D. Wiviott
- Benjamin M. Scirica
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital Moinhos de Vento (BR)
- Massachusetts General Hospital (US)
- Mount Sinai Hospital (US)
- Thrombolysis in Myocardial Infarction Study Group (US)
- University of Colorado Anschutz Medical Campus (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-10-27
- DOI
- https://doi.org/10.1093/eurjpc/zwaf693
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82