DOCK8 deficiency
DOCK8 deficiency is a severe inborn error of immunity with features of Tregopathies, actinopathies, and STAT3 signalling defects. Curative treatment with haematopoietic stem cell transplantation should be offered to these patients, and abolishes most of the symptoms, although allergic manifestations may persist.
Authors
- Andrew R. Gennery (ORCID: https://orcid.org/0000-0002-6218-1324)
- Michael H. Albert (ORCID: https://orcid.org/0000-0001-9143-3263)
Institutions
- Clinical Research Institute (US)
- Great North Children's Hospital (GB)
- University of Newcastle Australia (AU)
- Ludwig-Maximilians-Universität München (DE)
- Newcastle University (GB)
Publication Details
- Journal
- Current Opinion in Allergy and Clinical Immunology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1097/aci.0000000000001115
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00