The association of diabetes with Alzheimer's disease biomarkers and vascular burden across European aging and memory clinic cohorts
Diabetes mellitus (DM) was associated with lower odds of amyloid beta (Aβ) and phosphorylated tau (p-tau) pathology across clinical populations. DM was associated with total tau and medial temporal atrophy in cognitively normal individuals without Aβ pathology. DM may be associated with dementia through neurodegenerative pathways other than Alzheimer's disease.
Authors
- Jordi Salas‐Salvadó (ORCID: https://orcid.org/0000-0003-2700-7459)
- Søren Dalsgaard (ORCID: https://orcid.org/0000-0003-4659-0969)
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Johannes Streffer
- Giuseppe Fanelli (ORCID: https://orcid.org/0000-0001-7930-563X)
- Julius Popp (ORCID: https://orcid.org/0000-0002-0068-0312)
- Daniel Damian
- Pieter Jelle Visser (ORCID: https://orcid.org/0000-0001-8008-9727)
- Wiesje M. van der Flier (ORCID: https://orcid.org/0000-0001-8766-6224)
- Magda Tsolaki
- Sebastiaan Engelborghs (ORCID: https://orcid.org/0000-0003-0304-9785)
- Susana Jiménez‐Múrcia (ORCID: https://orcid.org/0000-0002-3596-8033)
- Pablo Martínez‐Lage
- Anouk den Braber (ORCID: https://orcid.org/0000-0002-3377-2627)
- Lutz Froelich (ORCID: https://orcid.org/0000-0003-1494-0813)
- Barbara Franke (ORCID: https://orcid.org/0000-0001-9254-7510)
- Inez H.G.B. Ramakers (ORCID: https://orcid.org/0000-0002-4747-2879)
- Nienke Legdeur (ORCID: https://orcid.org/0000-0002-0646-934X)
- Stephanie J. B. Vos
- Rik R. Vandenberghe (ORCID: https://orcid.org/0000-0001-6237-2502)
- Justine Moonen (ORCID: https://orcid.org/0000-0001-8260-8762)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Kateřina Veverová (ORCID: https://orcid.org/0000-0002-5845-1854)
- Willemijn J. Jansen (ORCID: https://orcid.org/0000-0001-9081-1496)
- Veerle van Gils (ORCID: https://orcid.org/0000-0001-8240-5367)
- Jakub Hort (ORCID: https://orcid.org/0000-0002-1080-3726)
- Mònica Bulló (ORCID: https://orcid.org/0000-0002-0218-7046)
- Janita Bralten (ORCID: https://orcid.org/0000-0003-1440-8675)
- Olivier Rouaud (ORCID: https://orcid.org/0000-0001-9767-8421)
- Geert Poelmans (ORCID: https://orcid.org/0000-0001-7039-6985)
- Yvonne Freund‐Levi (ORCID: https://orcid.org/0000-0001-6863-6679)
- Anders Wallin (ORCID: https://orcid.org/0000-0001-9506-0513)
- Markku Laakso
- Simon Lovestone
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Anette Hall
- Alberto Lleó
- Fernando Fernández‐Aranda (ORCID: https://orcid.org/0000-0002-2968-9898)
Institutions
- Allen Institute for Brain Science (US)
- Lundbeck (Denmark) (DK)
- Radboud University Nijmegen (NL)
- University of Antwerp (BE)
- University of Eastern Finland (FI)
- Charles University (CZ)
- Aristotle University of Thessaloniki (GR)
- Heidelberg University (DE)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Hospital de Sant Pau (ES)
- Bellvitge University Hospital (ES)
- Centre Hospitalier Universitaire Vaudois (CH)
- Radboud University Medical Center (NL)
- Warneford Hospital (GB)
- Karolinska Institutet (SE)
- Aarhus Business College (DK)
- Maastricht University (NL)
- University of Oxford (GB)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- University Hospital in Motol (CZ)
- University Hospital of Zurich (CH)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Central Institute of Mental Health (DE)
- Amsterdam Neuroscience (NL)
- Hôpital Orthopédique de la Suisse Romande (CH)
- UK Dementia Research Institute (GB)
- Universitair Ziekenhuis Brussel (BE)
- National Hospital for Neurology and Neurosurgery (GB)
- Fundacion CITA Alzheimer (ES)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- University College London (GB)
- Universitat Rovira i Virgili (ES)
- Universitat de Barcelona (ES)
- UCB Pharma (Belgium) (BE)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- University of Bologna (IT)
- University of Lausanne (CH)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70804
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Federation of Pharmaceutical Industries and Associations
- University College London
- European Commission
- ZonMw
- Generalitat de Catalunya
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- Horizon 2020 Framework Programme
- HORIZON EUROPE Framework Programme