Time-Restricted Eating and Metformin in Invasive Breast Cancer or DCIS: A Randomized, Phase IIb, Presurgical Trial. Preliminary Safety Analysis
In a context of rising cancer drug costs, this research explores a low-cost treatment to optimize breast cancer preventive intervention. The approach is safe and based on repurposed drugs that could enhance prevention strategies for obesity- and insulin-related cancers, offering immediate applicability to a large-scale trial in women at risk.
Authors
- Oriana Pala (ORCID: https://orcid.org/0000-0001-5484-2105)
- Nicoletta G. Gandolfo (ORCID: https://orcid.org/0009-0004-0884-8513)
- Sara Gandini (ORCID: https://orcid.org/0000-0002-1348-4548)
- Davide Serrano (ORCID: https://orcid.org/0000-0002-2945-4108)
- Marina Gualco
- Matteo Lazzeroni (ORCID: https://orcid.org/0000-0002-2162-4002)
- Brandy M. Heckman‐Stoddard (ORCID: https://orcid.org/0000-0003-1686-7154)
- Eileen Dimond (ORCID: https://orcid.org/0000-0001-7628-1783)
- M.C. García Lozano
- Saverio Minucci (ORCID: https://orcid.org/0000-0001-5678-536X)
- Stefano Spinaci (ORCID: https://orcid.org/0000-0002-9255-534X)
- Flavio Guasone
- Stefania Uncini
- Mariangela Rutigliani (ORCID: https://orcid.org/0000-0002-5773-0309)
- Chiara Arianna Accornero (ORCID: https://orcid.org/0000-0003-4226-164X)
- Mauro D’Amico (ORCID: https://orcid.org/0000-0001-5821-3410)
- Edward R. Sauter
- Tania Buttiron Webber (ORCID: https://orcid.org/0000-0002-3605-2828)
- Harriet Johansson (ORCID: https://orcid.org/0000-0002-4131-2030)
- Eduardo Vilar (ORCID: https://orcid.org/0000-0001-6404-3761)
- Emma Firpo
- Irene Maria Briata (ORCID: https://orcid.org/0000-0003-0767-0026)
- Aliana Guerrieri‐Gonzaga (ORCID: https://orcid.org/0000-0003-1915-1688)
- Andrea DeCensi (ORCID: https://orcid.org/0000-0003-2635-4491)
- Martino Oliva
- Bernardo Bonanni (ORCID: https://orcid.org/0000-0003-3589-2128)
- Lana A. Vornik (ORCID: https://orcid.org/0000-0002-1812-0305)
- Mattia Intra (ORCID: https://orcid.org/0000-0003-3739-1052)
- Parijatham S. Thomas (ORCID: https://orcid.org/0000-0003-2973-6639)
- Andrea Rattaro (ORCID: https://orcid.org/0000-0003-3119-4568)
- Monica Peresi
- Araceli García-González (ORCID: https://orcid.org/0000-0001-8785-9579)
- Paolo Veronesi (ORCID: https://orcid.org/0000-0001-8926-4106)
Institutions
- Champalimaud Foundation (PT)
- National Institutes of Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- Ente Ospedaliero Ospedali Galliera (IT)
- National Cancer Institute (US)
- Villa Torri Hospital (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Cancer Prevention Research
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1158/1940-6207.capr-25-0104
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Rising Tide Foundation
- University of Texas MD Anderson Cancer Center
- National Cancer Institute
- Janssen Research and Development