Deciphering the potential pathogeny of rare tracheal adenoid cystic carcinoma by single-cell RNA-sequencing
Our research showed that TACC might originate from ciliated epithelial cells. Abnormal gene expression triggered by external factors, along with the dysfunction of NK and T cells, are critical factors in the genesis and progression of TACC. Developing drugs that target MIF-CD74 signaling pathways may lead to breakthroughs in the treatment of TACC.
Authors
- Lijuan Zhang (ORCID: https://orcid.org/0000-0001-5833-2858)
- Bo Yang (ORCID: https://orcid.org/0000-0003-0612-5712)
- Yi Liu (ORCID: https://orcid.org/0000-0002-3965-6299)
- Jie Li (ORCID: https://orcid.org/0000-0002-9299-3251)
- Jinfeng Li (ORCID: https://orcid.org/0000-0002-1794-5129)
- Tao Wang (ORCID: https://orcid.org/0000-0001-7087-4596)
- Long Yi (ORCID: https://orcid.org/0009-0009-3100-792X)
- Haixu Hu
- Yanju Yu
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tlcr-2025-832
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00