Comparative outcomes of treatment with versus without definitive thoracic radiotherapy in locally advanced inoperable non-small cell lung cancer during the immunotherapy era: a Chinese real-world study

This study confirms that thoracic RT remains essential for inoperable LA-NSCLC in the immunotherapy era. An exploratory analysis suggests that a potential strategy could involve ≤4 cycles of CIT induction followed by concurrent CRT (cCRT) and immune checkpoint inhibitor maintenance. These findings encourage further investigation into RT integration within multimodal treatment, with 50-60 Gy appearing potentially comparable in selected patients.