Immunohistochemical analysis of p53 and LKB1 as predictive biomarkers of immune checkpoint inhibitor response in non-small cell lung cancer
The immunohistochemical profiles of p53 and LKB1 are associated with distinct immune microenvironment features. These markers may serve as surrogate predictors of ICI efficacy in patients with NSCLC.
Authors
- Yoshiyuki Oyama (ORCID: https://orcid.org/0000-0002-4222-5377)
- Yasuhiko Kitayama
- Tomo Tsunoda
- Hisaki Igarashi (ORCID: https://orcid.org/0009-0008-0490-3721)
- Kazuya Hattori
- Kazuo Tsuchiya (ORCID: https://orcid.org/0000-0001-5263-3238)
- Masaki Ikeda (ORCID: https://orcid.org/0000-0003-0076-4169)
- Taisuke Ito
- Takuro Akashi
Institutions
- Shizuoka Saiseikai General Hospital (JP)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tlcr-2025-782
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00