Single-cell RNA profiling reveals an immunosuppressive microenvironment in EGFR double-mutant non-small cell lung cancer
scFocuSCOPE precisely delineated tumor heterogeneity and immune suppression in <i>EGFR</i>-DM NSCLC. The complex immune landscape of <i>EGFR</i>-DM tumors offers valuable insights for future mechanistic studies and personalized therapies.
Authors
- Xuhui Guan
- Junwei Su (ORCID: https://orcid.org/0000-0001-7154-8928)
- Mei‐Mei Fang (ORCID: https://orcid.org/0009-0003-2801-7250)
- Jia Liu (ORCID: https://orcid.org/0000-0002-1021-9271)
- Xiao‐Cheng Lin
- Kejun Liu
- Hongrui Li (ORCID: https://orcid.org/0000-0002-2571-1883)
- Xu‐Chao Zhang (ORCID: https://orcid.org/0000-0002-4138-8115)
- Wen‐Zhao Zhong (ORCID: https://orcid.org/0000-0002-8917-8635)
- Li‐Xu Yan (ORCID: https://orcid.org/0000-0002-5584-4265)
- Yang Jiao
- Wendy Wu
- Jin-Ji Yang
- Hua-Jun Chen
- Xue-Ning Yang
Institutions
- Central South University (CN)
- Shantou University (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- Dongguan People’s Hospital (CN)
- Berry Oncology (China) (CN)
- Guangdong Academy of Medical Sciences (CN)
- Center for High Pressure Science & Technology Advanced Research (CN)
- Guangdong Provincial People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tlcr-2025-708
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81