Lung adenocarcinoma with ALK deletion of exons 6–20 with response to sequential ALK inhibitors: a case report
This case suggests that <i>ALK</i> internal deletions, even those affecting exon 20, demonstrate oncogenic potential and sensitivity to ALK inhibitors. ALK IHC remains an essential complementary test in cases of high clinical suspicion and inconclusive results using initial molecular testing.
Authors
- Sayaka Uda
- Kazuki Jinno
- Tatsuya Imabayashi (ORCID: https://orcid.org/0000-0002-6343-5306)
- Kohei Yamamoto (ORCID: https://orcid.org/0000-0002-2264-8401)
- Shunya Tanaka (ORCID: https://orcid.org/0000-0002-5495-987X)
- Tatsuya Yuba
- Toshiyuki Tanaka (ORCID: https://orcid.org/0000-0001-6647-3378)
- Chieko Takumi
Institutions
- Kyoto first Red Cross hospital (JP)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tlcr-2025-120
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00