Early de-escalation of empiric antibiotic therapy in neutropenic fever: a single-center, retrospective study
We implemented a policy to discontinue empiric antibiotics after 48 hours of defervescence in neutropenic fever with no identified clinical/microbiologic infection. Among patients with acute myeloid leukemia or hematopoietic stem cell transplant, early de-escalation was not associated with increased subsequent infection, decompensation, or mortality, supporting its safety and feasibility.
Authors
- Alla Keyzner
- Meenakshi Rana (ORCID: https://orcid.org/0000-0001-9366-5359)
- Michelle Evans (ORCID: https://orcid.org/0000-0002-5628-0502)
- Samantha E. Jacobs (ORCID: https://orcid.org/0000-0002-9770-886X)
- Zachary Mostel (ORCID: https://orcid.org/0000-0003-0077-464X)
- Risa Fuller (ORCID: https://orcid.org/0000-0003-3263-166X)
- John O Mascarenhas (ORCID: https://orcid.org/0000-0002-8400-0483)
- Douglas Tremblay
- Daniel Park
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Antimicrobial Stewardship & Healthcare Epidemiology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/ash.2025.10208
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00