A Case of Combined Small-cell Carcinoma and Adenocarcinoma of the Lung With <i>EGFR</i> Exon 19 Deletion Identified <i>via</i> Liquid Genomic Profiling
This case illustrates the clinical value of liquid biopsy in detecting actionable mutations in patients with mixed histological lung cancers where tissue-based testing is inconclusive. Liquid biopsy enabled a personalized therapeutic approach without the need for further invasive procedures. Such strategies may be essential in managing histologically and genomically heterogeneous tumors.
Authors
- Ayako Shiono (ORCID: https://orcid.org/0000-0001-6546-3864)
- Kyoichi Kaira (ORCID: https://orcid.org/0000-0001-5548-7686)
- Hisao Imai (ORCID: https://orcid.org/0000-0003-3097-4255)
- Kosuke Hashimoto (ORCID: https://orcid.org/0000-0003-3031-0635)
- Ou Yamaguchi (ORCID: https://orcid.org/0000-0001-7194-6459)
- Ryohei Ishii (ORCID: https://orcid.org/0000-0003-2486-1393)
- Hiroshi Kagamu
- Naozumi Hashimoto (ORCID: https://orcid.org/0000-0003-2337-629X)
- Yasutaka Fukuda
- Atsuto Mouri (ORCID: https://orcid.org/0000-0001-8704-8151)
- YU MIURA
Institutions
- Saitama International Medical Center (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- In Vivo
- Published
- 2025-10-29
- DOI
- https://doi.org/10.21873/invivo.14164
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00