Effect of Decay-accelerating Factor on LPS-induced Acute Lung Injury in the Rat
DAF deficiency increased baseline C3b and C5aR1 protein levels in lung tissue. LPS-induced inflammatory response and lung injury were augmented in <i>Daf<sup>-/-</sup></i> rats without further increase in C3b and in the absence of significant changes in the expression of membrane-bound complement regulatory proteins, DAF and Crry, or the anaphylatoxin receptor C5aR1.
Authors
- Ioanna Dimopoulou (ORCID: https://orcid.org/0000-0002-2219-7292)
- Maria G. Detsika (ORCID: https://orcid.org/0000-0003-4425-235X)
- Ioanna Nikitopoulou
- Stylianos E. Orfanos (ORCID: https://orcid.org/0000-0001-6186-6199)
- Αnastasia Kotanidou (ORCID: https://orcid.org/0000-0002-2508-500X)
Institutions
- National and Kapodistrian University of Athens (GR)
- Evangelismos Hospital (GR)
Publication Details
- Journal
- In Vivo
- Published
- 2025-10-29
- DOI
- https://doi.org/10.21873/invivo.14124
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00