Tripartite Motif-containing 22 Is Involved in TLR3-mediated Inflammatory Pathway in Rheumatoid Fibroblast-like Synoviocytes
Treatment of cultured RFLS with a TLR3 agonist led to the upregulation of <i>TRIM22</i> expression. <i>TRIM22</i> is regulated through the IFN-β and NF-κB-mediated pathways and TRIM22 positively regulates poly I:C-induced CCL5 and IFN-β expression. TRIM22 may have an important role in synovial inflammation associated with RA.
Authors
- Tatsuro Saruga (ORCID: https://orcid.org/0000-0002-1021-0867)
- Kazuki Oishi (ORCID: https://orcid.org/0000-0002-5418-0559)
- Kazuhiko Seya (ORCID: https://orcid.org/0000-0001-5866-7148)
- Akira Kurose (ORCID: https://orcid.org/0000-0002-1033-8481)
- Shogo Kawaguchi (ORCID: https://orcid.org/0000-0001-5599-1110)
- Eiji Sasaki (ORCID: https://orcid.org/0000-0002-4859-8473)
- Yasuyuki Ishibashi (ORCID: https://orcid.org/0000-0003-2180-7922)
- Tadaatsu Imaizumi (ORCID: https://orcid.org/0000-0002-1560-9359)
- Yuzuru Nakamura (ORCID: https://orcid.org/0000-0001-9676-3683)
- Kanichiro Wada (ORCID: https://orcid.org/0000-0002-1112-5656)
- Mayuki Tachizaki (ORCID: https://orcid.org/0009-0002-7343-9121)
- Hikaru Kristi Ishibashi
Institutions
- Hirosaki University (JP)
Publication Details
- Journal
- In Vivo
- Published
- 2025-10-29
- DOI
- https://doi.org/10.21873/invivo.14123
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00