Anamorelin in Cancer Cachexia: Gut Microbiota Effects and CONUT Score as a Predictor of Response
In this pilot study, anamorelin significantly increased body weight and suggested an improvement in appetite in patients with cancer and cachexia. No significant changes in overall QOL or gut microbiota diversity were detected at 6 weeks. The finding that a high baseline CONUT score may predict a lack of short-term weight gain warrants further investigation.
Authors
- Sawako Yoshiuchi
- Eri Matsumori
- Yoshiyuki Matsuo (ORCID: https://orcid.org/0000-0002-3183-4871)
- Shogen Boku (ORCID: https://orcid.org/0000-0002-5015-0379)
- Takayasu Kurata (ORCID: https://orcid.org/0000-0003-4123-3567)
- Takako Yasuda (ORCID: https://orcid.org/0000-0001-9063-8507)
- Koichiro Higasa (ORCID: https://orcid.org/0000-0003-4049-8256)
- Tatsuki Ikoma (ORCID: https://orcid.org/0000-0003-3758-3425)
Institutions
- Kansai Medical University (JP)
Publication Details
- Journal
- In Vivo
- Published
- 2025-10-29
- DOI
- https://doi.org/10.21873/invivo.14161
- Citations
- 1
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Kansai Medical University
- Japan Society for the Promotion of Science