Integration of Network Pharmacology, Molecular Docking, and Experimental Validation to Identify the Effect of EGCG on Alleviating Chondrocyte Inflammatory Damage by Targeting ER Stress-STAT3 Crosstalk
This study reveals that EGCG may ameliorate the metabolic imbalance of extracellular matrix (ECM) and inflammatory responses by modulating the activity of the ER stress-STAT3 crosstalk.
Authors
- Yongchun Ge (ORCID: https://orcid.org/0000-0002-0824-3977)
- Dao-Fang Ding (ORCID: https://orcid.org/0000-0003-4056-142X)
- Xuezong Wang
- Chung‐Feng Huang (ORCID: https://orcid.org/0000-0002-3367-068X)
- Liao-Lin Chen
- Jun‐Jie Yin (ORCID: https://orcid.org/0000-0003-0532-2116)
- Xubo Wu (ORCID: https://orcid.org/0000-0002-7593-6626)
- Jia‐Hui Luo (ORCID: https://orcid.org/0000-0002-8762-8428)
- Mingming Zhao
- Ting-Ting Meng
- Y. ZHAI
- Xinhui Huang (ORCID: https://orcid.org/0009-0004-1494-0543)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Second People's Hospital (CN)
- Shanghai Institute of Applied Physics (CN)
- Shuguang Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s564356
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34