Plasma and feces multiomics unveil cognition‐associated perturbations of chronic inflammatory pathways of the gut‐microbiota–brain axis
Examined gut microbiota, inflammation, and metabolic changes in cognitive impairment stages Early metabolic changes in feces detected before plasma alterations Observed shifts in gut microbiota and inflammation associated with cognitive decline Suggests potential for early biomarkers based on gut metabolites Calls for larger, longitudinal studies to validate findings.
Authors
- Cornelia M. van Duijn (ORCID: https://orcid.org/0000-0002-2374-9204)
- Rahel Park (ORCID: https://orcid.org/0000-0002-8751-2812)
- Amy C. Harms (ORCID: https://orcid.org/0000-0002-2931-4295)
- Giovanni Battista Frisoni (ORCID: https://orcid.org/0000-0001-7075-7082)
- Sabine Bos
- Farideh Hosseinkhani (ORCID: https://orcid.org/0000-0002-1880-6964)
- Thomas Hankemeier (ORCID: https://orcid.org/0000-0001-7871-2073)
- Moira Marizzoni (ORCID: https://orcid.org/0000-0003-3749-2988)
- Claire Chevalier (ORCID: https://orcid.org/0000-0003-0902-0756)
- Alida Kindt Dunjko
Institutions
- University of Geneva (CH)
- Leiden University (NL)
- Erasmus MC (NL)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Centre for Human Drug Research (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70844
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Universiteit Leiden
- Ministero della Salute
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Leids Universitair Medisch Centrum
- Hôpitaux Universitaires de Genève
- Fondation Segré
- Faculté de Médecine, Université de Genève