Efficacy of immunotherapy in gastrointestinal (GI) tumors with mismatch repair deficient (MMRd) unusual phenotype: an AGEO real-world study
Our findings underscore the need for dual testing and advocate for the presence of both MMRd-IHC and MSI-H for optimal immunotherapy response. Of note, complex MMR aberrations and isolated PMS2/MSH6 losses with MSI-H may represent promising candidates for enhanced immunotherapy efficacy.
Authors
- Marie Decraecker (ORCID: https://orcid.org/0000-0002-3304-2106)
- Emily Linda Alouani (ORCID: https://orcid.org/0000-0002-2303-118X)
- Méher Ben Abdelghani (ORCID: https://orcid.org/0000-0002-9105-6346)
- Marie Dutherage
- Janick Sèlves (ORCID: https://orcid.org/0000-0001-6122-7004)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Thérèse Masson
- Émilie Hafliger (ORCID: https://orcid.org/0000-0003-3666-1997)
- Thibault Mazard (ORCID: https://orcid.org/0000-0002-5644-9603)
- Marion Jaffrelot
- David Tougeron (ORCID: https://orcid.org/0000-0002-8065-9635)
- Thomas Aparicio (ORCID: https://orcid.org/0000-0001-8834-6927)
- Pauline Parent (ORCID: https://orcid.org/0000-0001-6072-7357)
- Romain Cohen (ORCID: https://orcid.org/0000-0001-9602-5162)
- Vincent Hautefeuille (ORCID: https://orcid.org/0000-0003-2735-6448)
- Géraldine Perkins (ORCID: https://orcid.org/0000-0002-4960-2534)
- Clélia Coutzac (ORCID: https://orcid.org/0000-0002-8347-6957)
- Frank A. Sinicrope (ORCID: https://orcid.org/0000-0002-2907-1000)
- Simon Pernot (ORCID: https://orcid.org/0000-0003-4580-585X)
- Francesco Sclafani (ORCID: https://orcid.org/0000-0003-0251-2627)
- Antoine Hollebecque (ORCID: https://orcid.org/0000-0003-2869-7551)
- Rosine Guimbaud (ORCID: https://orcid.org/0000-0002-8344-1762)
- Marie Müller (ORCID: https://orcid.org/0000-0002-5662-0650)
- Guillaume Roces
Institutions
- Université Libre de Bruxelles (BE)
- Mayo Clinic (US)
- Institut Jules Bordet (BE)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Université Rennes 2 (FR)
- Université de Poitiers (FR)
- Sorbonne Université (FR)
- Institut de Cancérologie Strasbourg (FR)
- Lille’s Cardiology Hospital (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Saint-Antoine (FR)
- Centre Léon Bérard (FR)
- Mayo Clinic in Arizona (US)
- Institut Bergonié (FR)
- Institut de Recherche en Cancérologie de Montpellier (FR)
- Centre Hospitalier de La Rochelle (FR)
- Hôpital Saint-Louis (FR)
- Université de Rennes (FR)
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2024-011436
- Citations
- 3
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.41