Clonally expanded effector CD4 <sup>+</sup> cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy
Overall, our study highlights the expansion and activation of CD4<sup>+</sup> CTLs in ICI-induced neurotoxicity, proposing these cells as potential targets for developing new biomarkers and therapeutic strategies to improve patient outcomes.
Authors
- Matthias Endres (ORCID: https://orcid.org/0000-0001-6520-3720)
- Leonie Müller‐Jensen (ORCID: https://orcid.org/0000-0002-6388-9375)
- Christian Schinke (ORCID: https://orcid.org/0000-0003-0199-9672)
- Petra Huehnchen (ORCID: https://orcid.org/0000-0002-6825-7270)
- Ambre Giguelay (ORCID: https://orcid.org/0000-0003-0417-1109)
- Smilla K. Maierhof (ORCID: https://orcid.org/0000-0002-3826-6096)
- Natasha Nambiar (ORCID: https://orcid.org/0009-0004-3538-8081)
- Patrick Maschmeyer (ORCID: https://orcid.org/0000-0002-1705-5302)
- Wolfgang Boehmerle (ORCID: https://orcid.org/0000-0001-7195-3894)
- Leif S. Ludwig (ORCID: https://orcid.org/0000-0002-2916-2164)
- Samuel Knauß (ORCID: https://orcid.org/0000-0002-3046-9075)
- Manpreet Meyer (ORCID: https://orcid.org/0009-0004-5700-8529)
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Max Delbrück Center (DE)
- German Center for Neurodegenerative Diseases (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Einstein Center for Neurosciences Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/jitc-2025-012350
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Corona-Stiftung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Berlin Institute of Health