Hypofractionated Radiotherapy for Prostate Cancer: A Comparative Study of Clinical Outcomes and Dosimetry Between Proton and Photon Therapy
Two-year biochemical control was comparable between proton- and photon- based HFRT in high-risk prostate cancer. Proton therapy demonstrated improved early PSA kinetics and reduced GU toxicity, supported by favorable dosimetric profiles. The identification of bladder V90% <11% as a planning constraint may guide treatment optimization. Further studies with longer follow-up are warranted to validate these benefits.
Authors
- Chun‐Te Wu (ORCID: https://orcid.org/0000-0002-2748-4493)
- Miao‐Fen Chen (ORCID: https://orcid.org/0000-0003-0932-0388)
- Wen‐Cheng Chen (ORCID: https://orcid.org/0000-0002-6335-8670)
- Yao‐Yu Wu (ORCID: https://orcid.org/0000-0002-6491-7059)
Institutions
- Chang Gung Memorial Hospital (TW)
- Chiayi Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- Cancer Management and Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/cmar.s546959
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council