Decreased Aryl Hydrocarbon Receptor Gene Expression and Polymorphic Variants Association with Increase COPD Risk
The presence of allele A and the GA genotype of the rs2066853 polymorphism in the AHR gene is significantly associated with COPD, suggesting a genetic predisposition. Moreover, reduced AHR expression in patients supports its key role in COPD pathogenesis.
Authors
- Mohammad Hossein Nicknam (ORCID: https://orcid.org/0000-0001-9132-1675)
- Maryam Edalatifard (ORCID: https://orcid.org/0000-0003-3669-5409)
- Hanieh Mojtahedi (ORCID: https://orcid.org/0000-0002-6494-6984)
- Alireza Abdollahi (ORCID: https://orcid.org/0000-0002-5714-967X)
- Narjes Soleimanifar (ORCID: https://orcid.org/0000-0002-8886-2902)
- Sara Assadiasl (ORCID: https://orcid.org/0000-0001-5244-3127)
- Alireza Asgari (ORCID: https://orcid.org/0000-0002-9448-2391)
- Maryam Sadr (ORCID: https://orcid.org/0000-0003-1214-8152)
Institutions
- Imam Khomeini Hospital (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/copd.s550884
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tehran University of Medical Sciences and Health Services