Self-Assembled Carrier Free Oligomeric Proanthocyanidin/Tetrandrine Nanoparticles Ameliorate Osteoarthritis via Anti-Inflammatory and Anti-Ferroptotic Pathways
In summary, our results demonstrate OPC-Tet NPs show good biocompatibility, and treatment effect. The treatment mechanism of anti-inflammation and anti-ferroptosis were also verified. The current research not only offers a new strategy to manage OA but also provides more possibilities for potential application of natural products.
Authors
- Weijie Li (ORCID: https://orcid.org/0000-0001-5922-6678)
- Huikun Chen (ORCID: https://orcid.org/0000-0002-2418-4639)
- Yao Huang (ORCID: https://orcid.org/0009-0008-4607-8475)
- Xie Wang
- Chengyuan Xing (ORCID: https://orcid.org/0000-0002-2714-8713)
- Wu Yu
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu Sport University (CN)
- Fourth People's Hospital of Sichuan Province (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/ijn.s531873
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81