Elemental imbalance and oxidative biomarker shifts in lumbar disc degeneration
These findings reveal substantial alterations in the micro- and macronutrient composition of degenerated IVDs, particularly for Zn, Mg, Ca, and P, suggesting that metabolic dysregulation and mineral imbalance contribute to disc pathology. The observed oxidative stress profile, characterized by lipid peroxidation and compensatory GPx activation, supports the involvement of redox imbalance in IVDD progression. Together, these results underscore the interplay between mineral homeostasis, oxidative stress, and disc degeneration, providing potential avenues for biomarker development and metabolic intervention in IVDD management.
Authors
- Paweł Rogoziński
- Dawid Sobański (ORCID: https://orcid.org/0000-0002-5525-6201)
- Beniamin Oskar Grabarek (ORCID: https://orcid.org/0000-0003-1633-7145)
- Rafał Staszkiewicz (ORCID: https://orcid.org/0000-0002-0781-6534)
- Roman Wojdyła (ORCID: https://orcid.org/0000-0003-4331-2875)
- Mateusz Rajchel (ORCID: https://orcid.org/0000-0003-4930-3443)
- Artur Chwalba (ORCID: https://orcid.org/0000-0001-5500-5579)
- Damian Strojny (ORCID: https://orcid.org/0009-0007-2324-3039)
- Jerzy Wieczorek (ORCID: https://orcid.org/0000-0001-7039-5974)
- Mateusz Miller
- Martyna Hoczela
- Katarzyna Wyczarska-Dziki
- Klaudia Skóra (ORCID: https://orcid.org/0009-0006-8548-3321)
Institutions
- Medical University of Silesia (PL)
- University of Agriculture in Krakow (PL)
- Cracow University of Technology (PL)
- Rehabilitation Research and Development Service (US)
- Sefako (Poland) (PL)
- University of Information Technology and Management in Rzeszow (PL)
- St. Raphael's Hospital (PK)
- 1 Military Clinical Hospital with Outpatient Clinic (PL)
- WSB University (PL)
- Andrzej Frycz Modrzewski Krakow University (PL)
- University of Rzeszów (PL)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fneur.2025.1662845
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00