Clinical characteristics and intensification patterns in subjects with “early” type 2 diabetes in Italy- an analysis from the AMD annals initiative

In real life, T2D could be considered as early in only ~ 8% of people. Among them, less than 10% received treatment intensification during the first year of observation, although the timing of the introduction of add-on GLD improved during time and drugs with cardiovascular benefit were often chosen as second-line GLD. In longitudinal analysis, of 42,786 early patients initially treated with metformin, 9.37% were prescribed an add-on treatment during 12 months, more frequently represented by SGLT2i, followed by GLP1-RAs and DPP4i. Mean level of HbA1c at treatment intensification improved over time, suggesting an encouraging trend through a proactive approach.

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Publication Details

Journal
Acta Diabetologica
Published
2025-10-30
DOI
https://doi.org/10.1007/s00592-025-02599-9
Citations
1
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
1.29
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Clinical characteristics and intensification patterns in subjects with “early” type 2 diabetes in Italy- an analysis from the AMD annals initiative

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Clinical characteristics and intensification patterns in subjects with “early” type 2 diabetes in Italy- an analysis from the AMD annals initiative

Salvatore Corrao, Antonio Nicolucci, Francesco Prattichizzo, Giuseppina Tiziana Russo, Antonio Ceriello, Alberto Rocca, Alessandro Cuttone, Salvatore De Cosmo, Graziano Di Cianni, Valeria Manicardi, Giuseppe Lucisano, Riccardo Candido
article en
1 citations

Abstract

In real life, T2D could be considered as early in only ~ 8% of people. Among them, less than 10% received treatment intensification during the first year of observation, although the timing of the introduction of add-on GLD improved during time and drugs with cardiovascular benefit were often chosen as second-line GLD. In longitudinal analysis, of 42,786 early patients initially treated with metformin, 9.37% were prescribed an add-on treatment during 12 months, more frequently represented by SGLT2i, followed by GLP1-RAs and DPP4i. Mean level of HbA1c at treatment intensification improved over time, suggesting an encouraging trend through a proactive approach.

Acta Diabetologica
University of Messina (IT), University of Trieste (IT), Casa Sollievo della Sofferenza (IT), MultiMedica (IT), Department of Health (ES), University of Palermo (AR), Ospedale Bassini (IT), Ospedale di Livorno (IT), Center for Outcomes Research and Clinical Epidemiology (IT), University of Palermo (IT)
Openalex Percentile: Top 14%
Diabetes Treatment and Management
1.29
DOIOpen Access PDFOpenAlex
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