Neural Signatures of Flattened Emotional Experience in Patients With Early Multiple Sclerosis: A Bayesian Approach
Our findings of increased FC and BR in DLPFC and amygdala in MS patients with flattened emotional experience point to a disease-related adaptive upregulation of the EP network. The latter is interpreted as emotion regulation of heightened sensitivity of amygdala activity to negative emotional content via increased fronto-temporal functional connectivity.
Authors
- Hagen Kunte (ORCID: https://orcid.org/0000-0002-6609-6995)
- René M. Gieß (ORCID: https://orcid.org/0009-0001-4705-7683)
- Judith Bellmann–Strobl (ORCID: https://orcid.org/0000-0003-2615-1643)
- Friedemann Paul (ORCID: https://orcid.org/0000-0002-6378-0070)
- Thomas D. Hälbig (ORCID: https://orcid.org/0000-0002-0971-833X)
- Torsten Wüstenberg (ORCID: https://orcid.org/0000-0001-8408-2864)
Institutions
- Max Delbrück Center (DE)
- Heidelberg University (DE)
- Zurich Insurance Group (Switzerland) (CH)
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Micro Focus (United States) (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1002/brb3.70987
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft