In Vitro Metabolite Profiling of 4,4‐Diaminodiphenylmethane Using Human Liver S9 Fractions and LC‐Orbitrap HRMS: In Silico Toxicity Studies of Its Metabolites
The Orbitrap LC-HRMS platform enabled comprehensive identification and characterization of in vitro hepatic metabolic profiles of MDA. The predicted toxicological profiles and the discovery of additional metabolite formation beyond the known acetylation pathway provided new insights that can enhance toxicological risk assessment of MDA.
Authors
- Sridhar Chinthakindi (ORCID: https://orcid.org/0000-0002-8272-2159)
- Radhika Kawathe
- Leela Sairam Andhela (ORCID: https://orcid.org/0009-0009-8872-6415)
Institutions
- Manipal Academy of Higher Education (IN)
- Institute of Bioinformatics (IN)
- Institute of Bioinformatics and Applied Biotechnology (IN)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1002/rcm.10164
- Citations
- 2
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 1.87