Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies
This study provides an in-depth immunological characterization of the spike-specific T-cell response in PwMS under DMTs, evaluating immunological biomarkers whose relevance may extend beyond COVID-19 for studying immune responses to other infections and vaccinations.
Authors
- Francesca Colavita (ORCID: https://orcid.org/0000-0003-0640-8667)
- Stefania Notari
- Alessandro Sette (ORCID: https://orcid.org/0000-0001-7013-2250)
- Assunta Navarra (ORCID: https://orcid.org/0000-0002-3662-4312)
- Carla Tortorella (ORCID: https://orcid.org/0000-0001-9037-7300)
- Shalom Haggiag (ORCID: https://orcid.org/0000-0002-5569-4121)
- Maria Esmeralda Quartuccio
- Claudio Gasperini (ORCID: https://orcid.org/0000-0002-3959-4067)
- Anna Maria Gerarda Altera
- Alessandra Aiello (ORCID: https://orcid.org/0000-0003-2681-9383)
- Fabrizio Maggi (ORCID: https://orcid.org/0000-0001-7489-5271)
- Serena Ruggieri (ORCID: https://orcid.org/0000-0001-5287-3290)
- Silvia Meschi (ORCID: https://orcid.org/0000-0003-0924-993X)
- Emanuele Nicastri (ORCID: https://orcid.org/0000-0002-5606-8712)
- Gilda Cuzzi (ORCID: https://orcid.org/0000-0002-4305-2199)
- Delia Goletti (ORCID: https://orcid.org/0000-0001-8360-4376)
- Eleonora Cimini (ORCID: https://orcid.org/0000-0002-2659-0868)
- Simonetta Galgani
- Valentina Vanini (ORCID: https://orcid.org/0000-0001-8476-964X)
- Andrea Salmi (ORCID: https://orcid.org/0000-0001-9141-7909)
- Luca Prosperini (ORCID: https://orcid.org/0000-0003-3237-6267)
- Alba Grifoni (ORCID: https://orcid.org/0000-0002-2209-5966)
- Vincenzo Puro (ORCID: https://orcid.org/0000-0003-0291-4490)
Institutions
- La Jolla Institute for Immunology (US)
- University of California San Diego (US)
- Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1682049
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute