Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies

This study provides an in-depth immunological characterization of the spike-specific T-cell response in PwMS under DMTs, evaluating immunological biomarkers whose relevance may extend beyond COVID-19 for studying immune responses to other infections and vaccinations.

Authors

Institutions

Publication Details

Journal
Frontiers in Immunology
Published
2025-10-30
DOI
https://doi.org/10.3389/fimmu.2025.1682049
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies

Francesca Colavita, Stefania Notari, Alessandro Sette, Assunta Navarra et al.
Frontiers in Immunology
SARS-CoV-2 and COVID-19 Research
article

Minimal association between Th1-specific responses to COVID-19 vaccines and SARS-CoV-2 breakthrough infections in multiple sclerosis patients receiving disease-modifying therapies

Francesca Colavita, Stefania Notari, Alessandro Sette, Assunta Navarra, Carla Tortorella, Shalom Haggiag, Maria Esmeralda Quartuccio, Claudio Gasperini, Anna Maria Gerarda Altera, Alessandra Aiello, Fabrizio Maggi, Serena Ruggieri, Silvia Meschi, Emanuele Nicastri, Gilda Cuzzi, Delia Goletti, Eleonora Cimini, Simonetta Galgani, Valentina Vanini, Andrea Salmi, Luca Prosperini, Alba Grifoni, Vincenzo Puro
article en

Abstract

This study provides an in-depth immunological characterization of the spike-specific T-cell response in PwMS under DMTs, evaluating immunological biomarkers whose relevance may extend beyond COVID-19 for studying immune responses to other infections and vaccinations.

Frontiers in ImmunologyVol. 16
La Jolla Institute for Immunology (US), University of California San Diego (US), Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani (IT), Azienda Ospedaliera San Camillo-Forlanini (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Ministero della Salute
Openalex Percentile: Top 63%
SARS-CoV-2 and COVID-19 Research
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.