Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

SGLT2 inhibitors were associated with enhanced cardiac function and reduce cardiac stress markers in HF patients post-AMI, suggesting their potential as an adjunctive therapy. Lower baseline LVEF and higher NT-proBNP levels may predict better response, suggesting their utility in personalized treatment strategies. This was a retrospective single-center study, and further prospective trials are needed to confirm these findings.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-10-30
DOI
https://doi.org/10.3389/fphar.2025.1693420
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

Haiping Du, Hui Xu, Jinwei Bao
Frontiers in Pharmacology
Diabetes Treatment and Management
article

Efficacy and influencing factors analysis of SGLT2 inhibitors in treating heart failure following acute myocardial infarction

Haiping Du, Hui Xu, Jinwei Bao
article en

Abstract

SGLT2 inhibitors were associated with enhanced cardiac function and reduce cardiac stress markers in HF patients post-AMI, suggesting their potential as an adjunctive therapy. Lower baseline LVEF and higher NT-proBNP levels may predict better response, suggesting their utility in personalized treatment strategies. This was a retrospective single-center study, and further prospective trials are needed to confirm these findings.

Frontiers in PharmacologyVol. 16
Yantaishan Hospital (CN)
Openalex Percentile: Top 57%
Diabetes Treatment and Management
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