Identification of immunogenic KIF5B-RET fusion neopeptides driving immune stimulation in tumor specific CD8+ T cells
This study demonstrates a robust pipeline for identifying and validating immunogenic neoantigens from chimeric RNAs to design personalized cancer vaccines with high immunogenicity and low cross-reactivity.
Authors
- Dinler A. Antunes (ORCID: https://orcid.org/0000-0001-7947-6455)
- Sakuni Rankothgedera
- Micah Castillo (ORCID: https://orcid.org/0009-0003-5727-8118)
- Preethi H. Gunaratne (ORCID: https://orcid.org/0000-0002-6487-3463)
- Martiela Vaz de Freitas (ORCID: https://orcid.org/0000-0003-4178-6604)
- Shiyanth Thevasagayampillai
- Janet E. Lewis
- Cole Woody
- Randa El‐Zein (ORCID: https://orcid.org/0000-0002-0750-4143)
- A. Kandasamy
Institutions
- Houston Methodist (US)
- Baylor College of Medicine (US)
- Baylor Genetics (US)
- University of Houston (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1635810
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Institutes of Health
- National Cancer Institute