Bangpungtongsung-san alleviates depressive-like behavior and metabolic disturbances in high-fat diet-induced obesity: mechanisms involving inflammation, CREB/BDNF signaling, and NMDA receptor modulation
BTS ameliorated depression-like behaviors and metabolic dysfunction in HFD-induced obesity through coordinated modulation of inflammation, BDNF signaling, NMDAR expression, and 5-HT neurotransmission in the HPC. These findings support BTS as a promising multi-target candidate for treating comorbid depression and obesity.
Authors
- Changsop Yang (ORCID: https://orcid.org/0000-0003-1277-3329)
- Yujin Choi (ORCID: https://orcid.org/0000-0003-4371-6239)
- Ui‐Jin Bae (ORCID: https://orcid.org/0000-0001-9984-1798)
- No Soo Kim (ORCID: https://orcid.org/0000-0003-1437-708X)
- Boram Lee (ORCID: https://orcid.org/0000-0003-4631-7372)
- Mi Young Lee (ORCID: https://orcid.org/0000-0002-3308-340X)
Institutions
- Korea Institute of Oriental Medicine (KR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fphar.2025.1565592
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Institute of Oriental Medicine