Anti-inflammatory effects of Frondanol, a nutraceutical extract from Cucumaria frondosa, via modulation of NF-κB and MAPK pathways in LPS-induced RAW 264.7 cells
These results suggest that Frondanol exerts its anti-inflammatory effects through suppression of both NF-κB and MAPK signalling pathways, leading to reduced production of inflammatory mediators and cytokines. Given its efficacy and lack of cytotoxicity, Frondanol may hold strong potential as a nutraceutical agent for the prevention and management of chronic inflammatory diseases.
Authors
- Thomas E. Adrian (ORCID: https://orcid.org/0000-0002-5051-1111)
- Reem Kais Jan (ORCID: https://orcid.org/0000-0002-1685-5594)
- Hardik Ghelani (ORCID: https://orcid.org/0000-0001-5960-7702)
- Hala Altaher (ORCID: https://orcid.org/0009-0005-6318-3697)
- Peter D. Collin
- Marah Tabbal
- Sally Badawi
- Kerat Hanspal
- Lana Talo
- Sami Talo
- Hadil Sarsour
Institutions
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Coastside Bio Resources (United States) (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fphar.2025.1683630
- Citations
- 1
- Primary Topic
- Advances in Cucurbitaceae Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Al Jalila Foundation
- Mohammed Bin Rashid University of Medicine and Health Sciences