1-stearoyl-2-arachidonoyl-driven B Cell metabolic dysregulation in chronic rhinosinusitis with nasal polyps: insights from Mendelian randomization and single-cell RNA sequencing
This integrated study advances understanding of immune-metabolic crosstalk in CRSwNP pathogenesis, highlighting the role of metabolite-influenced B cell subsets in shaping the immune microenvironment, thereby suggesting novel therapeutic targets.
Authors
- Ying Lin (ORCID: https://orcid.org/0000-0002-3876-5653)
- Lei Cao (ORCID: https://orcid.org/0000-0002-0755-6488)
- Yifang Sun
- Shuyue Wang (ORCID: https://orcid.org/0000-0001-8452-5602)
- Jian Wu (ORCID: https://orcid.org/0000-0003-0087-3744)
- Yu Feng (ORCID: https://orcid.org/0000-0003-0034-6397)
- Chang-Ying LIU
- Maomao Ai
- Qian Zhang (ORCID: https://orcid.org/0000-0003-4516-3455)
Institutions
- Jinan University (CN)
- The First People's Hospital of Guiyang (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fphar.2025.1719897
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00