Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation
<i>AKR1A1</i> lactylation plays a pivotal role in the metabolic-immune regulatory axis of osteoporosis, contributing to metabolic reprogramming and immune microenvironment remodeling. Through involvement in the <i>SPP1-CD44</i> signaling pathway, it mediates communication between monocytes and macrophages, and may serve as a novel biomarker and therapeutic target for early diagnosis and intervention in osteoporosis.
Authors
- Huanan Li (ORCID: https://orcid.org/0000-0002-1976-2895)
- Qinqin Deng (ORCID: https://orcid.org/0000-0002-5518-0796)
- Zichen Shao
- Weikang Sun
- Weidong Liang (ORCID: https://orcid.org/0000-0002-8290-3216)
- Jianfeng Wu (ORCID: https://orcid.org/0000-0001-6003-9810)
- Ling Cheng (ORCID: https://orcid.org/0009-0005-1268-2875)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1680305
- Citations
- 2
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 2.30