Immune suppression in MTAP-deficient cancers via glutamate metabolism and CXCL10 downregulation
These findings uncover a novel link between glutamate metabolism and immune modulation in MTAP-deficient tumors. Our study provides mechanistic and preclinical support for targeting glutamate pathways to both suppress tumor growth and convert immune-cold tumors into more immunoresponsive states, offering a promising strategy to enhance ICI efficacy in this challenging cancer subtype.
Authors
- Qi‐Sheng Hong
- Ching‐Hsien Chen (ORCID: https://orcid.org/0000-0002-4211-9988)
- Wen-Hsin Chang (ORCID: https://orcid.org/0000-0002-8501-6276)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-6990-5324)
Institutions
- Taipei Medical University (TW)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1634342
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tobacco-Related Disease Research Program
- University of California, Davis
- Office of the President, University of California
- Comprehensive Cancer Center, University of California, Davis