Is systemic inflammation a missing link between oral microbiome and oral squamous cell carcinoma? Results from multi-omics integration analyses
Our multi-omics integration suggests that systemic inflammation, particularly through IL-22 and CCL5 upregulation, serves as a mechanistic link between specific oral bacteria and OSCC risk, which could provide new strategies for OSCC prevention and early intervention.
Authors
- Qingrong Deng
- Baochang He (ORCID: https://orcid.org/0000-0002-5357-2171)
- Jing Wang (ORCID: https://orcid.org/0000-0001-6080-7998)
- Fa Chen (ORCID: https://orcid.org/0000-0002-5792-9211)
- Lingjun Yan
- Yu Qiu (ORCID: https://orcid.org/0000-0003-1272-8720)
- Lisong Lin (ORCID: https://orcid.org/0000-0003-2676-4351)
- Bin Shi (ORCID: https://orcid.org/0000-0003-1732-3052)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.1080/20002297.2025.2574326
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47