Adipose-derived stem cell exosomes suppress NLRP3-mediated neuronal pyroptosis to attenuate seizures in a kainic acid-induced temporal lobe epilepsy model
ADSC-Exos exert neuroprotective effects in temporal lobe epilepsy in association with regulation of the NLRP3-associated pyroptosis pathway, thereby suppressing neuroinflammation and neuronal death, highlighting their potential therapeutic value.
Authors
- Siqi Ding (ORCID: https://orcid.org/0000-0002-7565-4549)
- Zhihui Dong (ORCID: https://orcid.org/0000-0002-3754-2458)
- Yucang He (ORCID: https://orcid.org/0000-0003-3643-3564)
- Songyun Zhao (ORCID: https://orcid.org/0000-0003-0542-1085)
- Wanying Chen (ORCID: https://orcid.org/0000-0002-2913-8201)
- Jinsong Zhou (ORCID: https://orcid.org/0000-0001-7688-4373)
- Yanming Chen (ORCID: https://orcid.org/0000-0001-6902-5327)
- Hao Dai (ORCID: https://orcid.org/0000-0003-0226-9292)
- E. Yajun
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Yiwu Science and Technology Research Institute (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1691814
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00