Proteomic analysis of exosomes from Brucella abortus-infected macrophages reveals possible mechanisms of immune evasion and host modulation
Exosomes from <i>B. abortus</i>-infected macrophages exhibit dynamic proteomic remodeling that affects immune-related pathways, changes that may contribute to bacterial survival within the host. The presence of both host and bacterial-derived proteins within these vesicles suggests their potential relevance in brucellosis pathogenesis and highlights them as candidates worthy of further exploration as biomarkers or therapeutic targets.
Authors
- María R. Aburto (ORCID: https://orcid.org/0000-0001-5806-251X)
- Leonardo A. Gómez (ORCID: https://orcid.org/0000-0003-3946-8754)
- Ivan Alvarado (ORCID: https://orcid.org/0000-0002-5470-3639)
- Ángel Oñate (ORCID: https://orcid.org/0000-0002-4358-1015)
- Francisco I. Alvarez (ORCID: https://orcid.org/0000-0002-2977-6043)
- Felipe Del Canto (ORCID: https://orcid.org/0000-0001-5912-0283)
- Vicente Arriagada (ORCID: https://orcid.org/0009-0000-6701-9636)
- Roberto Vidal (ORCID: https://orcid.org/0000-0003-4223-1985)
- Ítalo Ferrari
- José Barrales
Institutions
- Universidad de Santiago de Chile (CL)
- University of Concepción (CL)
- University of Chile (CL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1685245
- Primary Topic
- Brucella: diagnosis, epidemiology, treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00