Abnormal inter-hemispheric functional cooperation in blepharospasm
This study identifies increased inter-hemispheric functional connectivity (FC) within key motor-related brain regions in blepharospasm. The observed hyperconnectivity in the putamen and precentral gyrus may reflect a compensatory neural mechanism to counteract motor dysfunction. These findings provide novel insights into the pathophysiology of blepharospasm and suggest that modulating inter-hemispheric communication may be a potential therapeutic target.
Authors
- Benjamin P. Liu (ORCID: https://orcid.org/0000-0003-0122-3866)
- Hualiang Li (ORCID: https://orcid.org/0000-0003-0126-2056)
- Chengjun Song (ORCID: https://orcid.org/0009-0005-6413-1370)
- Yue‐De Yang (ORCID: https://orcid.org/0000-0003-1579-7561)
- Yingzhu Chen (ORCID: https://orcid.org/0000-0002-2110-236X)
- Yian Gu (ORCID: https://orcid.org/0000-0002-4297-1548)
- Shu-Fang Wang (ORCID: https://orcid.org/0000-0003-0879-2527)
- Jian-Ping Liu
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Yancheng Third People's Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fneur.2025.1660039
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province