Periodontal therapy mitigates inflammation via TNF-α reduction and improves glycolipid metabolism in diabetic patients: a cross-sectional cohort study
Systematic periodontal therapy effectively reduces local and systemic inflammation, improves glycemic control, and ameliorates glycolipid metabolic disorders in patients with T2DM and periodontitis. The strong interrelationships observed, particularly within the GCF, underscore the potential role of TNF-α as a key mediator in the mouth-systemic metabolic interplay.
Authors
- Yuqing Guo (ORCID: https://orcid.org/0000-0001-5232-0629)
- Shanshan Dong (ORCID: https://orcid.org/0000-0002-2557-3361)
- Aige Yang
- Huimin Zhou (ORCID: https://orcid.org/0000-0001-8297-2003)
- Ning Zhang (ORCID: https://orcid.org/0009-0009-8108-6910)
- Yiman Guo
- Lina Wang (ORCID: https://orcid.org/0000-0003-3665-5706)
- Xincheng Zhang (ORCID: https://orcid.org/0000-0002-7251-1032)
Institutions
- Hebei Medical University (CN)
- Shijiazhuang University (CN)
- Third Hospital of Hebei Medical University (CN)
- Stomatology Hospital (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-30
- DOI
- https://doi.org/10.3389/fendo.2025.1668695
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University